Autocoids & Related Drugs MCQs


1. Histamine exerts the following actions except:

A. Dilatation of large blood vessels

B. Dilatation of small blood vessels

C. Stimulation of isolated guineapig heart

D. Itching

Answer: [   D  ]


2. Fall in blood pressure caused by larger doses of histamine is blocked by:

A. H1 antihistaminics alone

B. H2 antagonists alone

C. Combination of H1 and H2 antagonists

D. None of the above

Answer: [   D  ]


3. The following statement about histamine is not correct:

A. It is the sole mediator of immediate hypersensitivity reaction

B. It plays no role in delayed hypersensitivity reaction

C. It serves as a neurotransmitter in the brain

D. All types of histamine receptors are G protein coupled receptors

Answer: [   D  ]


4. Histamine is involved as a mediator in the following pathological condition:

A. Delayed hypersensitivity reaction

B. Inflammation

C. Carcinoid syndrome

D. Variant angina

Answer: [   D  ]


8. The drug that can directly release histamine from mast cells without involving antigen-antibody reaction is:

A. Aspirin

B. Procaine

C. Morphine

D. Sulfadiazine

Answer: [   D  ]


9. Autacoids differ from hormones in that:

A. Autacoids are involved only in the causation of pathological states

B. Autacoids do not have a specific cell/tissue of origin

C. Autacoids generally act locally at the site of generation and release

D. Both ‘B’ and ‘C’ are correct

Answer: [   D  ]


10.  Which of the following is a selective H1 receptor agonist:

A. 4-methyl histamine

B. Impromidine

C. 2-Thiazolyl ethylamine

D. Chlorpheniramine

Answer: [   C  ]


10. The action of histamine that is not mediated through H1  receptors is:

A. Release of EDRF from vascular endothelium resulting in vasodilatation

B. Direct action on vascular smooth muscle causing vasodilatation

C. Bronchoconstriction

D. Release of catecholamines from adrenal medulla

Answer: [   B   ]