BETA ADRENERGIC BLOCKING AGENTS

Beta-blockers are competitive antagonists that block the receptor sites for endogenous catecholamines (Adrenaline and Noradrenaline) on adrenergic beta receptors of sympathetic nervous system.

    1. NONSELECTIVE (β1 and β2)

a. Without intrinsic sympathomimetic activity

Propranolol

Sotalol

Timolol

b. With intrinsic sympathomimetic activity

Pindolol

c. With additional α-blocking property

Labetalol

Carvedilol

 

2. CARDIOSELECTIVE (β1)

Metoprolol

Atenolol

Acebutolol

Bisoprolol

Esmolol

Betaxolol

Celiprolol

Nebivolol

 

GENERATION WISE CLASSIFICATION

 

1. First Generation (older, nonselective)

Propranolol

Timolol

Sotalol

Pindolol

2. Second Generation (β2 selective)

Metoprolol

Atenolol

Acebutolol

Bisoprolol

Esmolol

3. Third Generation (with additional α blocking and/ or vasodilator property)

Labetalol

Carvedilol

Celiprolol

Nabivolol

BETA ADRENERGIC BLOCKING AGENTS
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