DRUGS ACTING ON AUTONOMIC GANGLIA

 

GANGLIONIC STIMULANTS

Agents that mimic neural transmission by stimulation of the nicotinic receptors on postganglionic autonomic neurons. Drugs that indirectly augment ganglionic transmission by increasing the release or slowing the breakdown of acetylcholine

1. Selective nicotinic agonists:

a. Natural alkaloids:

Nicotine

Lobeline

b. Synthetic drugs:

Dimethylphenyl piperazinium iodide (DMPP)

Tetramethyl ammonium

Varenicline

 

2. Nonselective/muscarinic agonists:

Acetylcholine

Carbachol

Pilocarpine

Anticholinesterases

 

 

GANGLION BLOCKERS

A ganglionic blocker (or ganglioplegic drug) is a type of medication that inhibits transmission between preganglionic and postganglionic neurons in the Autonomic Nervous System, often by acting as a nicotinic receptor antagonist. Nicotinic acetylcholine receptors are found on skeletal muscle, but also within the route of transmission for the parasympathetic and sympathetic nervous system.

 

1. Competitive blockers

a. Quaternary ammonium compounds: 

Hexamethonium

Pentolinium

b. Amines (secondary/tertiary)

Mecamylamine

Pempidine

c. Monosulfonium compound:

Trimethaphan camforsulfonate

 

2. Persistent depolarising blockers:

Nicotine

Anticholinesterases

 

DRUGS ACTING ON AUTONOMIC GANGLIA
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